The EU AI Act establishes the first regulatory framework for AI. As AI rapidly evolves, the European Commission's AI Office develops and implements policies that ensure safety, accountability, and innovation. This keynote outlines the EU’s approach to regulating General Purpose AI under the AI Act. It highlights key initiatives led by the AI Office and how to engage with them. It includes the Codes of Practice for regulatory guidance, a Tender on AI Safety to build evaluation and enforcement capacity, and a Network of Evaluators to advance scientific evaluations. Additionally, it presents the Scientific Panel, which aims to provide technical and scientific input for the enforcement of the AI Act.